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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are usually focused on the practical aspects of the study design, including recruitment and consent, adherence, and the use of routinely available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and included participants from different geographic areas. This type of heterogeneity is essential for pragmatic trials to be valid and helps to reduce the chance of bias in the results. However excessive heterogeneity could result in issues with the design of the trial.

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The aim of pragmatic trials is to mimic real-life situations and achieve maximum validity externally. They are typically commissioned by practitioners and policy makers to inform their decision making. They are also a good method of determining the cause-effect relationship between an intervention and its outcomes. They should not, however, be used to replace the need for explanation studies.

The pragmatism concept is controversial, and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which confirm the clinical or physiological hypothesis and pragmatic trials that inform policy and practice decisions. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool tried to define the elements of a practical study which includes recruitment, design, delivery of the intervention and its follow-up.

There is a positive increase in the number pragmatic trials that are published. A recent Medline search using the terms naturalistic and pragmatic, limited to controlled trials that are randomized (RCTs), yielded 34 articles, as shown in red in Figure 2. This is an indication that the health science community is becoming more sensitive to the issue of pragmatics. However, 프라그마틱 슬롯버프 체험 (visit this website link) it is important to remember that the majority of these trials were conducted in primary care settings.